2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-17504BS2
    Rosuvastatin-13C,d3 sodium
    Rosuvastatin-13C,d3 sodium is 13C and deuterated labeled Rosuvastatin sodium (HY-17504B). Rosuvastatin Sodium is a competitive HMG-CoA reductase (HMGCR) inhibitor, with an IC50 of 11 nM. Rosuvastatin Sodium potently blocks hERG current with an IC50 of 195 nM. Rosuvastatin Sodium reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin Sodium effectively lowers low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.
    Rosuvastatin-13C,d3 sodium
  • HY-A0132S14
    N-Acetyl-D-glucosamine-d3 77369-11-0
    N-Acetyl-D-glucosamine-d3 (N-Acetyl-2-amino-2-deoxy-D-glucose-d3) is deuterium labeled N-Acetyl-D-glucosamine. N-Acetyl-D-Glucosamine (N-Acetyl-2-amino-2-deoxy-D-glucose), the D isomer of N-acetylglucosamine, is an orally active monosaccharide derivative of glucose with anti-tumor and anti-inflammation properties. N-Acetyl-D-Glucosamine is also a bacterial metabolite, which is found in Escherichia coli. N-Acetyl-D-Glucosamine can induce yeast-mycelial conversion in Candida albicans. N-Acetyl-D-Glucosamine also enhances healing of cartilaginous injuries in rabbits.
    N-Acetyl-D-glucosamine-d3
  • HY-B1617AS2
    Zuclomiphene d10 Citrate salt
    Zuclomiphene d10 Citrate salt is deuterium labeled Zuclomiphene (citrate). Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent.
    Zuclomiphene d10 Citrate salt
  • HY-N0229S19
    L-Alanine-1,2-13C2 920314-10-9
    L-Alanine-1,2-13C2 (Alanine-13C2) is 13C labeled L-Alanine. L-Alanine is a non-essential amino acid, involved in sugar and acid metabolism, increases immunity, and provides energy for muscle tissue, brain, and central nervous system.
    L-Alanine-1,2-13C2
  • HY-W001909R
    Myosmine (Standard) 532-12-7
    Myosmine (Standard) is the analytical standard of Myosmine. This product is intended for research and analytical applications. Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM.
    Myosmine (Standard)
  • HY-W004260A
    Arachidate sodium 13257-34-6
    Arachidate (sodium) is an ester product.
    Arachidate sodium
  • HY-W004263R
    1-Eicosanol (Standard) 629-96-9
    1-Eicosanol (Standard) (Arachidyl alcohol (Standard)) is the analytical standard of 1-Eicosanol (HY-W004263). This product is intended for research and analytical applications. 1-Eicosanol is a natural compound with antioxidant activity found in Justicia insularis leaves. 1-Eicosanol can be used as an antioxidant.
    1-Eicosanol (Standard)
  • HY-W004305S
    Hexadecanal-d5 2703602-66-6
    Hexadecanal-d5 (Palmitaldehyde-d5) is deuterium labeled Hexadecanal. Hexadecanal (Palmitaldehyde) , a volatile long-chain aliphatic aldehyde, is emitted from human feces, skin, and breath. The receptor for hexadecanal(OR37B) is highly conserved across mammals. Hexadecanal may exert its effects by modulating functional connectivity between the brain substrates of social appraisal and the brain substrates of aggressive execution. Also, Hexadecanal is confirmed to be highly deterrent to the ant Lasius niger. Hexadecanal is promising for the research of startle responses and aggression
    Hexadecanal-d5
  • HY-W008848A
    DMT-L-dG(ib) Phosphoramidite 141846-56-2
    DMT-L-dG(ib) Phosphoramidite (Compound 20D) is a nucleoside phosphoramidite that can be used for nucleotide assembly on solid supports.
    DMT-L-dG(ib) Phosphoramidite
  • HY-W010224R
    3-Amino-4-hydroxybenzoic acid (Standard) 1571-72-8
    Vasicine (hydrochloride) (Standard) is the analytical standard of Vasicine (hydrochloride). This product is intended for research and analytical applications. Vasicine hydrochloride (peganine hydrochloride) is a quinazoline alkaloid isolated from Justicia adhatoda. Vasicine (peganine) possesses anti- tuberculosis activity.
    3-Amino-4-hydroxybenzoic acid (Standard)
  • HY-W010381R
    2-Methylsuccinic acid (Standard) 498-21-5
    2-Methylsuccinic acid (Standard) is the analytical standard of 2-Methylsuccinic acid. This product is intended for research and analytical applications. 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy.
    2-Methylsuccinic acid (Standard)
  • HY-W010396R
    Pantolactone (Standard) 599-04-2
    Pantolactone (Standard) is the analytical standard of Pantolactone. This product is intended for research and analytical applications. Pantolactone is an endogenous metabolite.
    Pantolactone (Standard)
  • HY-W010410S
    Oct-1-en-3-ol-d3 1335435-98-7
    Oct-1-en-3-ol-d3 is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities.
    Oct-1-en-3-ol-d3
  • HY-W010448R
    Imidazol-1-yl-acetic acid (Standard) 22884-10-2
    Imidazol-1-yl-acetic acid (Standard) is the analytical standard of Imidazol-1-yl-acetic acid. This product is intended for research and analytical applications. Imidazol-1-yl-acetic acid is an endogenous metabolite.
    Imidazol-1-yl-acetic acid (Standard)
  • HY-W010510R
    DL-Norvaline (Standard) 760-78-1
    DL-Norvaline (Standard) is the analytical standard of DL-Norvaline. This product is intended for research and analytical applications. DL-Norvaline, a derivative of L-norvaline, L-norvaline is a non-competitive inhibitor of arginase.
    DL-Norvaline (Standard)
  • HY-W010549R
    2-Methylcyclohexanone (Standard) 583-60-8
    3-tert-Butyl-4-methoxyphenol (Standard) is the analytical standard of 3-tert-Butyl-4-methoxyphenol. This product is intended for research and analytical applications. 3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system.
    2-Methylcyclohexanone (Standard)
  • HY-W010697S
    Cholesteryl linoleate-d11
    Cholesteryl linoleate-d11 is deuterium labeled Cholesteryl linoleate. Cholesteryl linoleate is shown to be the major cholesteryl ester contained in LDL and atherosclerotic lesions.
    Cholesteryl linoleate-d11
  • HY-W011120R
    Ethyl docosa-4,7,10,13,16,19-hexaenoate (Standard) 84494-72-4
    Ethyl docosa-4,7,10,13,16,19-hexaenoate (Standard) is the analytical standard of Ethyl docosa-4,7,10,13,16,19-hexaenoate. This product is intended for research and analytical applications. Ethyl cis-4,7,10,13,16,19-Docosahexaenoate, the ethyl ester of Docosahexaenoate (DHA), is enriched in the ethyl ester fraction by the selective alcoholysis of fatty acid ethyl esters originating from tuna oil with lauryl alcohol.
    Ethyl docosa-4,7,10,13,16,19-hexaenoate (Standard)
  • HY-W011240R
    Hydroflumethiazide (Standard) 135-09-1
    Hydroflumethiazide (Standard) is the analytical standard of Hydroflumethiazide. This product is intended for research and analytical applications. Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas.
    Hydroflumethiazide (Standard)
  • HY-W011303S
    Phytosphingosine-d7
    Phytosphingosine-d7 (4-Hydroxysphinganine-d7) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes.
    Phytosphingosine-d7
Cat. No. Product Name / Synonyms Application Reactivity